In 1991, Gregor Cevc popularized the word “transfersome” and its meaning. In its broadest sense, a transfersome isa complex aggregation that is very durable and versatile. Its ideal structure is an aqueous core surrounded by aflexible vesicle with a complicated lipid bilayer. The vesicle may self-regulate and optimize due to theinterdependence of the bilayer’s composition and structure. Because of this special characteristic, transfersomesmay effectively carry controlled drugs while getting across a number of transport obstacles. Because transdermaldelivery is safe and convenient, it is especially beneficial. Benefits include avoiding first-pass metabolism,optimizing therapeutic response, reducing adverse effects, and guaranteeing stable medication concentrations. Thepenetration of substances through the skin may be improved by a number of chemical and physical techniques,including lipid vesicles (liposomes, proliposomes), nonionic surfactant vesicles (niosomes, proniosomes),iontophoresis, and sonophoresis. The very flexible membranes of phospholipid vesicles, sometimes referred to astranssomes, further promote transdermal medication administration. Transfersomes can effectively permeate theskin thanks to their membranes, which also enable them to adjust to the skin’s natural water gradient andmechanical stressors. Transfersome membranes may be optimized for flexibility and stability by varying the mix ofsurface-active molecules, therefore mitigating the likelihood of vesicle rupture. All things considered,transfersomes are a major breakthrough in drug delivery technology, especially when it comes to improving theeffectiveness and distribution of transdermal medications (Cevc et al., 1991). Download pdf